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Kierszenbaum Histologia E Biologia Celular Pdf

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by Muecke J.F.. Kierszenbaum AL. Histologia e Biologia Celular. The diploid complement of mitotic figures was found in 25 . RSO. Avidin/Biotin Blocking Kit. LanCarta .

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The proximal convoluted and distal tubules of the kidney are made up of a nephron (for details see Figure          6.4.1.1.) Each nephron (left and right) contains two key nephron segments, the ascending and the distal segments. The ascending segment is a 12 to 15 µm long region that produces a vast majority of the urine in the proximal tubule. The distal tubule, a 10 to 30 µm long region, has a high capacity for resorption and secretion of a number of solutes. The distal tubule is much longer (i.e., 30 µm in dog) than the ascending tubule (i.e., 12 µm in dog). Because the urine must be concentrated to prevent excessive loss, the length of the distal tubule is long enough to provide a cumulative effect of solute concentration without increasing urine flow too much. This explains why the urine is not very concentrated in the proximal tubule. Histologically, the kidney is made up of many nephrons that are loosely arranged and separated by adipose tissue. The epithelium of the proximal and distal tubules is covered by the brush border, a series of microvilli that jut out from the apical surface. The brush border is formed of a closely packed array of microvilli. Between each pair of microvilli are interdigitations or intramembrane projections. The brush border contains a host of specialized membrane proteins, which function in reabsorption of the glomerular filtrate and secretion of various substances.
The main function of the kidney is to regulate the concentration of ions in the body fluid and maintain a pH that is appropriate to the body’s metabolic needs. However, the kidney also plays a significant role in the homeostatic balance of the body, maintaining blood pressure, electrolyte balance, acid/base homeostasis and fluid balance, although it does so without involving hormones as other body organs do. This physiologic role of the kidney was recognized early in the 20th century by physiologists, but it was not until this century that a detailed understanding of the functional anatomy of the nephron and the complex processes of urine formation began to emerge. (See Figure       

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