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The Gayatri Mantra is an important part of the Vedic ritual of Aahihsaar Dattawaam. In the Vedas, the Gayatri-mantra was recited as part of the Aahihsaar ritual on the new moon day and as part of the Panchamanagatika ritual on the new moon day. The Gayatri Mantra was used by the initiated to invoke or invoke power in the Sun God who was the source of direct manifestation of Shri Vaishnaav, but was also of Prakritic origin. It is a mantra of the Saptashatwas (seven words) of the Rigveda and the Vishnu Sutra and is an important part of the Sama Veda. There are many Gayatri Mantras, the most important one is the Gayatri Mantra. Gayatri Mantra is translated as the most luminous mantra, which includes the essence of the entire Vedas. This mantra is essentially the most enduring creation of God himself. The highest, the purest, the strongest mantra Gayatri is an extensive mantra meaning the timeless, the ever-moving and the whole essence of the Vedic mantras. The Gayatri Mantra is also known as the Shakti Mantra. The Gayatri Mantra is recited during sunrise and sunset. Now, it has been translated into several languages: Sanskrit, Hindi, Urdu, Telugu, Tamil, Malayalam, Burmese and Kannada.Dichloroacetate enhances the antitumor efficacy of the anti-EGFR monoclonal antibody cetuximab through stabilization of HIF-1α/Bcl-2 interactions.
Dichloroacetate (DCA) is an effective inhibitor of glycolysis and displays selective toxicity against hypoxic cells. The hypoxia inducible factor (HIF) pathway has been shown to induce resistance to EGFR-tyrosine kinase inhibitors (EGFR-TKIs) in human cancer models. In the current study, we used RKO and Calu-3 human CRC cell lines to demonstrate that DCA was capable of overcoming chemoresistance induced by hypoxia. DCA treatment led to a significant increase in the expression and activity of the prolyl-4-hydroxylase (P4H) complex in RKO cells, resulting in the stabilization of HIF-1α. When combined with the EGFR-T

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