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Our previous studies demonstrated that tissue-type plasminogen activator (tPA) alters the distribution of plasminogen in both cultured tumor cells and in vivo. To determine if tPA could also alter the distribution of the plasminogen activator urokinase (uPA) in tumor cells, the distribution of uPA in R3230AC rat mammary adenocarcinoma cells was examined. Using an immunohistochemical analysis, we observed that uPA was concentrated in the perinuclear region of nonpermeabilized cells, which is also the subcellular region of tPA accumulation, and could only be partially redistributed to the cell membrane after uPA was permeabilized. Studies using a pulse-chase protocol demonstrated that the majority of uPA was internalized in the perinuclear region after 6 hr of chase and was found on the cell membrane after 12 hr of chase. To determine if tPA or uPA altered the distribution of their respective substrates, two plasminogen-fluorescein isothiocyanate (FITC) conjugates were prepared. These probes were used to examine changes in plasminogen distribution in response to tPA in R3230

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Founded by Dr. Mary C. Johnson  PhD, a research scientist, during her doctoral studies, PharmaGuide, Inc. is a 501 (c)(3) not-for-profit, not-for-government organization founded by, and dedicated to, the advancement of pharmacotherapy in helping people.

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Bharat Biotech Laboratories Limited the manufacturer of Covaxin available for £160 in Pakistan. The company is part of the Shantakari group of companies and has been producing many other vaccines like PentaVax1, PentaVax2 and ErvaxVax.

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