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The prognostic significance of anti-her-2/neu status in relation to its role in the metastatic cascade remains controversial. Anti-neu status was determined by immunohistochemistry in 1,284 patients treated with modified radical mastectomy between 1976 and 1992. The patients were grouped into three categories: node-negative patients with no anti-neu staining; node-positive patients with no anti-neu staining; and node-negative patients with anti-neu staining. The antibody (HercepTest) was obtained from Dako (Carpinteria, CA). The relative risks of recurrence and death within 10 years, estimated by Cox’s proportional hazards model, were compared for these three groups. A total of 240 patients had node-negative tumors and 126 (43.3%) had anti-neu staining of their primary tumor. Of the remaining nodes from 44 node-negative patients with anti-neu staining, 6 (13.6%) showed micrometastatic disease, and none of 58 node-positive patients had micrometastatic disease. Patients with node-negative tumors and anti-neu staining had a higher risk of recurrence and death than did those without anti-neu staining (p = 0.023 and p = 0.012, respectively). Multivariate analysis showed the prognostic impact of anti-neu status in node-negative patients remained significant for recurrence (p = 0.012) but not for death (p = 0.199

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