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Class Switching and Memory B Cells Accumulate in Germinal Centers of the Small Intestine in Response to Helminth Infection.
Humans usually harbor a huge number of commensal microbes, which can lead to chronic low-grade inflammation. Th2-mediated immunoglobulin (Ig) E responses to the microbiota cause inflammatory diseases. The immunologic mechanisms underlying the association between helminth infection and low-grade inflammation remain unclear. Here, we show that peristaltic wave-like movement of the intestinal tract during helminth infection breaks the contact between microbiota and intestinal epithelium, thereby inhibiting the accumulation of commensal bacteria in the intestinal lamina propria. As a result, IgE-mediated mast cell activation is attenuated and Th2 responses are suppressed, leading to prevention of Th2 inflammation. In the present study, the accumulation of Class Switching (CS) B cells and memory B cells was found in germinal centers (GCs) of the small intestine in response to helminth infection. These B cells exhibited CS reaction, which is a critical event for isotype switching. Thus, the interplay between microbial antigens, intestinal peristalsis, and the immune system provides us with a new conceptual framework that helps us to understand and treat inflammatory disorders of the human body.# RUN: not llvm-mc -triple thumbv7a -show-encoding -mcpu=thumbv7em -mattr=+v6 -disassemble &1 | FileCheck %s

ldr\tbx, = 0x1234
# CHECK: error: illegal instruction encoding
# CHECK: ldr\twbx, = 0x1234
# CHECK: ^

The present invention is directed to a display system for displaying a plurality of trading assets and, more particularly, to a display system that may be implemented with the use of smart cards.
As an ever increasing number of trading instruments are available to investors, it is often difficult for an investor to keep track of all of these instruments and their associated

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